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KMID : 0858620080120010031
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Korean Journal of Audiology
2008 Volume.12 No. 1 p.31 ~ p.35
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The Effect between Combined Oral and Intravenous Antiviral Agent Therapy for Idiopathic Sudden Sensorineural Hearing Loss
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Cho Han-Kyu
Hur Dong-Gu
Ahn Seong-Ki
Jeon Sea-Yuong
Kim Jin-Pyeong
Park Jung-Je
Kim Dae-Woo
Shim Hyun-Seok
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Abstract
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Background and Objectives: Of various theories that have been proposed for the etiology of idiopathic sudden sensorineural hearing loss, viral infection is the most widely accepted etiology and many physicians use antiviral agents for the treatment of disease. There are intravenous and oral agents for antiviral agents, with intravenous agents being relatively more highly priced. When the pharmacokinetics of oral antiviral agent is considered, it is possible that there might not be much difference in the therapeutic results between intravenous antiviral agent and oral antiviral agent, and thus the use of oral agent should be recommended. The purpose of this study is therefore to evaluate the therapeutic efficacy, cost-benefit and side effects between the intravenous antiviral agent and the oral antiviral agent for sudden sensorineural hearing loss patients.
Subjects and Mathods: From January 2001 to March 2004, 106 patients with ISSNHL were treated at Gyeongsang National University Hospital. Of these, 33 patients who had the identical prognosis factor were selected and divided into two groups. Group A included 13 patients and were treated with intraveonus antiviral agents. Gruop B included 20 patients and were treated with oral antiviral agents. We examined the recovery rate, cost, and side effects of both group.
Results: The recovery rate of Group A and B were 53.85% and 70%, respectively. There is no statistical significant difference between the two groups. The cost was significantly higher in group A than in group B. There were no side effects in either of the groups.
Conclusions: These results suggest that there is no difference in the therapeutic results between the groups A and B. However, when cost is considered, the use of oral antiviral agent could be recommended.
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KEYWORD
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ISSNHL, Antiviral agent
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